Lactate dehydrogenase A promotes nasopharyngeal carcinoma progression through the TAK1/NF-κB Axis.

Yingzi LiLanfang ChenQiaochong ZhengGuanxin LiuMengjiao WangShupei WeiTao Chen

Published in: Molecular biology reports (2024)

Our results suggest that LDHA and its major metabolite lactate drive NPC progression by regulating TAK1 and its downstream NF-κB signaling, which could become a therapeutic target in NPC.

Keyphrases

signaling pathway
lps induced
pi k akt
nuclear factor
oxidative stress
inflammatory response