Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children.

Brittany P Boribong Thomas J LaSalleYannic C BartschFelix EllettMaggie E LoiselleJameson P DavisAnna L K GonyeSoroush HajizadehJohannes KreuzerShiv PillaiWilhelm HaasAndrea EdlowAlessio FasanoGalit AlterDaniel IrimaMoshe Sade-FeldmanLael M Yonker

Published in: bioRxiv : the preprint server for biology (2021)

Circulating SARS-CoV-2 antigen:antibody immune complexes in Multisystem Inflammatory Syndrome in Children (MIS-C) drive hyperinflammatory and coagulopathic neutrophil extracellular trap (NET) formation and neutrophil activation pathways, providing insight into disease pathology and establishing a divergence from neutrophil signaling seen in acute pediatric COVID-19.

Keyphrases

sars cov
coronavirus disease
young adults
respiratory syndrome coronavirus
oxidative stress
liver failure
case report
respiratory failure
drug induced
acute respiratory distress syndrome