P53 Gene Expression and Nitric Oxide Levels after Artemisinin-Caffeine Treatment in Breast, Lungs and Liver of DMBA-Induced Tumorigenesis.

Titilope Modupe DokunmuSandra C OparaNgozi Awa ImagaOmiete U AwaniDavid O EnomaBababode I Adelani

Published in: Asian Pacific journal of cancer prevention : APJCP (2023)

This study shows a dose-dependent synergistic anticancer effects of caffeine and artemisinin combination on p53 gene and nitric oxide regulation hence can mitigate tumor development.

Keyphrases

nitric oxide
gene expression
nitric oxide synthase
hydrogen peroxide
plasmodium falciparum
dna methylation
diabetic rats
high glucose
copy number
cancer therapy
drug induced
oxidative stress
drug delivery
combination therapy
transcription factor