Effect of oral naloxone on opioid-induced constipation in methadone maintenance treatment patients, a double-blind, placebo-control, clinical trial.

Shaghayegh Akhgarandouz Mohammad Moshiri Leila Etemad Bita Dadpour Majid Khadem Rezaiyan Nasser Vahdati-Mashhadian

Published in: Irish journal of medical science (2024)

Oral naloxone at doses of 0.5 and 2 mg/day was significantly more effective than placebo on OIC in MMT. However, the dose of 4 mg induced intolerable OWS.

Keyphrases

clinical trial
high glucose
diabetic rats
end stage renal disease
double blind
newly diagnosed
phase iii
drug induced
chronic pain
prognostic factors
endothelial cells
pain management
open label
patient reported outcomes
combination therapy