Levels of ADAM10 are reduced in Alzheimer's disease CSF.

Aitana Sogorb-EsteveMaría-Salud García-AyllónJohan GobomJordi AlomHenrik ZetterbergKaj BlennowJavier Sáez-Valero

Published in: Journal of neuroinflammation (2018)

Several forms of ADAM10 are present in CSF, mainly assembled as high-molecular weight complexes. The determination of the levels of mature forms of CSF-ADAM10 may be useful as a biomarker for AD.

Keyphrases

cerebrospinal fluid
cognitive decline
solid phase extraction
mass spectrometry
high resolution
liquid chromatography