Celogentin mimetics as inhibitors of tubulin polymerization.
Varsha Jagannath ThombareJames A HoldenEric C ReynoldsNeil M O'Brien-SimpsonCraig A HuttonPublished in: Journal of peptide science : an official publication of the European Peptide Society (2019)
Bicyclic analogues of celogentin C have been synthesized in which the side chain-side chain cross-links are replaced by thioether bonds. Several of the simplified bicyclic peptides displayed potent inhibition of tubulin polymerization.