BAF Complexes and the Glucocorticoid Receptor in Breast Cancers.
Nicholas DietrichJackson A HoffmanTrevor K ArcherPublished in: Current opinion in endocrine and metabolic research (2020)
Breast cancers are a diverse group of diseases and are often characterized by their expression of receptors for hormones such as estrogen and progesterone. Recently another steroid hormone receptor, the glucocorticoid receptor (GR) has been shown to be a key player in breast cancer progression, metastasis, and treatment. These receptors bind to chromatin to elicit transcriptional changes within cells, which are often inhibited by the structure of chromatin itself. Chromatin remodeling proteins, such as Brahma-related gene 1 (BRG1), function to overcome this physical inhibition of transcription factor function and have been linked to many cancers including breast cancer. Recent efforts to understand the interactions of BRG1 and GR, including genomic and single cell analyses, within breast cancers may give insight into personalized medicine and other potential treatments.
Keyphrases
- transcription factor
- gene expression
- genome wide
- dna damage
- single cell
- genome wide identification
- induced apoptosis
- copy number
- dna binding
- childhood cancer
- estrogen receptor
- binding protein
- physical activity
- mental health
- dna methylation
- high throughput
- rna seq
- cell death
- cell proliferation
- cell cycle arrest
- long non coding rna
- human health
- drug induced