Spermidine Crosslinked Gellan Gum-Based "Hydrogel Nanofibers" as Potential Tool for the Treatment of Nervous Tissue Injuries: A Formulation Study.
Barbara ViganiCaterina ValentinoGiuseppina SandriCarla Marcella CaramellaFranca Ferrari BridgersSilvia RossiPublished in: International journal of nanomedicine (2022)
SP and GL allowed the production of homogenous GG-based nanofibers, which preserved their structure after contact with aqueous media and showed a good compatibility with a neural cell line. After local application at the injury site, nanofibers should support and guide axonal outgrowth, releasing SP in a controlled manner.