Imaging Mass Cytometry Reveals Predominant Innate Immune Signature and Endothelial-Immune Cell Interaction in Juvenile Myositis Compared to Lupus Skin.
Jessica L TurnierChristine M YeeJacqueline A MadisonSyed M RizviCeline C BerthierFei WenJ Michelle KahlenbergPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Our findings identify immune cell population differences, including CD14+ macrophages, pDCs, and CD8+ T cells, in juvenile DM skin compared to cSLE skin, and highlight a predominant innate immune signature and endothelial cell-immune cell interaction in juvenile DM, providing insight into candidate cell populations and interactions to better understand disease-specific pathophysiology.