Cyanidin-3-O-glucoside plays a protective role against renal ischemia/ reperfusion injury via the JAK/STAT pathway.

Yufeng Xiong Jun Jian Honglin Yu Jiejun Wu Hu Mao Ruikang Feng Lei Wang Yonghong Jian Xiuheng Liu

Published in: Acta cirurgica brasileira (2023)

The results demonstrated that C3G blocked renal apoptosis and ERS protein expression by preventing reactive oxygen species (ROS) production after I/R via the JAK/STAT pathway, suggesting that C3G may be a potential therapeutic agent for renal I/R injury.

Keyphrases

reactive oxygen species
ischemia reperfusion injury
oxidative stress
cell death
cell cycle arrest
signaling pathway
pi k akt