Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates.

Daniela Bumbaca YadavJanice A MaloneyKristin R WildsmithReina N FujiWilliam J MeilandtHilda SolanoyYanmei LuKun PengBlair WilsonPamela ChanKapil GadkarAndrew KoskyMarisa GooAnn DaughertyJessica A CouchThomas KeeneKaren HayesLisa Jungbauer NikolasDeanna LaneRobert SwitzerEric AdamsRyan J WattsKimberly Scearce-LevieSaileta PrabhuLisa ShaferDeepak R ThakkerKeith HildebrandJasvinder K Atwal

Published in: British journal of pharmacology (2017)

I.c.v. administration of anti-BACE1 resulted in enhanced BACE1 target engagement and inhibition, with a corresponding dramatic reduction in CNS Aβ concentrations, due to enhanced brain exposure to antibody.

Keyphrases

resting state
white matter
functional connectivity
low dose
cerebral ischemia
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