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Programmably engineered stochastic RNA nanowalker for ultrasensitive miRNA detection.

Dan ZhuDongxia ZhaoYang HuTianhui WeiTong SuShao SuJie ChaoLian-Hui Wang
Published in: Chemical communications (Cambridge, England) (2024)
A programmably engineered stochastic RNA nanowalker powered by duplex-specific nuclease (DSN) is developed. By utilizing poly-adenine-based spherical nucleic acids (polyA-SNA) to accurately regulate the densities of DNA tracks, the nanowalker showcases its capability to identify miRNA-21, miRNA-486, and miRNA-155 with quick kinetics and attomolar sensitivity, positioning it as a promising option for cancer clinical surveillance.
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