Mitochondrial DNA Variants in Patients with Liver Injury Due to Anti-Tuberculosis Drugs.

Li-Na LeeChun-Ta HuangChia-Lin HsuHsiu-Ching ChangI-Shiow JanJia-Luen LiuJin-Chuan SheuJann-Tay WangPeter Wei-Lun LiuHuei-Shu WuChing-Nien ChangMing-Chia Lee

Published in: Journal of clinical medicine (2019)

Variants in complex I's subunit 1 and 5 genes might affect respiratory chain function and predispose isoniazid-induced liver injury when exposed to hydrazine, a metabolite of isoniazid and a complex II inhibitor.

Keyphrases

copy number
mitochondrial dna
liver injury
drug induced
mycobacterium tuberculosis
genome wide
dna methylation
pulmonary tuberculosis
adverse drug
fluorescent probe
gene expression
hiv aids
genome wide identification