Pre-analytical stability of serum biomarkers for neurological disease: neurofilament-light, glial fibrillary acidic protein and contactin-1.
Zoë Y G J van LieropInge M W VerberkKees W J van UffelenMarleen J A Koel-SimmelinkLisanne In 't VeldJoep KillesteinCharlotte E TeunissenPublished in: Clinical chemistry and laboratory medicine (2022)
Overall, the serum biomarkers tested were relatively unaffected by variations in sample handling. For serum NfL, we recommend storage at RT before centrifugation at 2-8 °C up to 6 h or at RT up to 24 h. For serum CNTN1, we advise a maximum of two freeze-thaw cycles. Our results confirm and expand on recently launched consensus standardized operating procedures.