HIV-1 Drug Resistance Detected by Next-Generation Sequencing among ART-Naïve Individuals: A Systematic Review and Meta-Analysis.
Fei OuyangDefu YuanWenjing ZhaiShanshan LiuYing ZhouHaitao YangPublished in: Viruses (2024)
In this study, we found that next-generation sequencing facilitates a more sensitive detection of HIV-1 drug resistance than SGS. The high prevalence of PDR emphasizes the importance of baseline resistance and assessing the threshold for optimal clinical detection using NGS.
Keyphrases
- antiretroviral therapy
- sensitive detection
- hiv infected
- hiv positive
- loop mediated isothermal amplification
- human immunodeficiency virus
- hiv testing
- hiv aids
- hepatitis c virus
- men who have sex with men
- copy number
- quantum dots
- circulating tumor
- south africa
- gene expression
- real time pcr
- dna methylation
- label free
- genome wide