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Calcium-containing scaffolds induce bone regeneration by regulating mesenchymal stem cell differentiation and migration.

Rubén Aquino-MartínezAlcira P AngeloFrancesc Ventura Pujol
Published in: Stem cell research & therapy (2017)
Specific CaSO4 concentrations induce bone regeneration of calvarial defects in part by acting on the host's undifferentiated MSCs and promoting their migration. Progenitor cell recruitment is followed by a gradual increment in osteoblast gene expression. Moreover, CaSO4 regulates BMP-2-induced MSC migration by differentially activating the PI3K/AKT pathway. Altogether, these results suggest that CaSO4 scaffolds could have potential applications for bone regeneration.
Keyphrases
  • bone regeneration
  • gene expression
  • mesenchymal stem cells
  • tissue engineering
  • umbilical cord
  • dna methylation
  • bone marrow
  • diabetic rats
  • drug induced
  • human health