Calcium-containing scaffolds induce bone regeneration by regulating mesenchymal stem cell differentiation and migration.
Rubén Aquino-MartínezAlcira P AngeloFrancesc Ventura PujolPublished in: Stem cell research & therapy (2017)
Specific CaSO4 concentrations induce bone regeneration of calvarial defects in part by acting on the host's undifferentiated MSCs and promoting their migration. Progenitor cell recruitment is followed by a gradual increment in osteoblast gene expression. Moreover, CaSO4 regulates BMP-2-induced MSC migration by differentially activating the PI3K/AKT pathway. Altogether, these results suggest that CaSO4 scaffolds could have potential applications for bone regeneration.