ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK.
Benjamin Meir JacobsLuisa SchalkAngie DunneAntonio ScalfariAshwini NandoskarBruno GranCharles A MeinCharlotte SellersCord SpilkerDavid RogElisa VisentinElizabeth Lindsey BezzinaEmeka UzochukwuEmma TallantyreEva WozniakEve SacreGhaniah Hassan-SmithHelen L FordJade HarrisJoan BradleyJoshua BreedonJudith BrookeKarim L KreftKatherine Tuite DaltonKatila GeorgeMaria PapachatzakiMartin O'MalleyMichelle PeterMiriam MattoscioNeisha RhuleNikos EvangelouNimisha VinodOuti QuinnRamya ShamjiRashmi KaimalRebecca BoultonRiffat TanveerRod MiddletonRoxanne MurrayRuth BellfieldSadid HoqueShakeelah PatelSonia RajStephanie GumusStephanie MitchellStephen SawcerTarunya ArunTatiana PogrebanTerri-Louise BrownThamanna BegumVeronica AntoineWaqar RashidAlastair J NoyceEli SilberHuw MorrisGavin GiovannoniChu-Yueh GuoPublished in: BMJ open (2023)
Recruitment will continue over the next 10 years. Genotyping and genetic data quality control are ongoing. Within the next 3 years, we aim to perform initial genetic analyses of susceptibility and severity with a view to replicating the findings from European-ancestry studies. In the long term, genetic data will be combined with other datasets to further cross-ancestry genetic discoveries.