Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence.

George BatshonJinan ElayyanOmar QiqEli ReichLouisa Ben-AderetLeonid KandelAmir HazeJürgen SteinmeyerVeronique LefebvreHong ZhangJennifer ElisseeffYves HenrotinAli MobasheriMona Dvir-Ginzberg

Published in: Annals of the rheumatic diseases (2020)

Increased levels of serum NT/CT SIRT1 ratio correlated with moderate OA in both mice and humans, stemming at least in part from non-senescent chondrocyte apoptosis, possibly a result of prolonged inflammatory insult.

Keyphrases

oxidative stress
image quality
dual energy
computed tomography
contrast enhanced
knee osteoarthritis
ischemia reperfusion injury
positron emission tomography
endoplasmic reticulum stress
cell death
high intensity
magnetic resonance imaging
type diabetes
signaling pathway