Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis.
Boris HugleAnastasia SchippersNadine FischerKim OhlBernd DeneckeFabio TicconiBas VastertIvan G CostaJohannes-Peter HaasKlaus TenbrockPublished in: Arthritis research & therapy (2018)
Using transcription factor motif enrichment, this study identifies novel putative pathways in sJIA (STAT4, BCL6) implicating B cell activation at an earlier stage than predicted in refractory disease. The implication of BCL-6 dependent pathways argues for occurrence of autoimmunity early within the process of sJIA chronification. Transcriptional regulation of HLA-DRB1, a recently described independent genetic risk factor, in combination with its cooperating partner CD74 in patients where sJIA is confirmed, supports pathogenic involvement in alterations in antigen presentation during sJIA.
Keyphrases
- transcription factor
- juvenile idiopathic arthritis
- genome wide
- dna binding
- ejection fraction
- end stage renal disease
- cell proliferation
- newly diagnosed
- prognostic factors
- risk assessment
- dna methylation
- disease activity
- human immunodeficiency virus
- copy number
- rheumatoid arthritis
- hiv infected
- binding protein
- genome wide identification