Sex Differences in Diurnal Sodium Handling During Diet-Induced Obesity in Rats.

Reham H SolimanChunhua JinCrystal M TaylorEmile Moura Coelho da SilvaDavid M Pollock

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

These data identify diet-induced obesity as a sex-specific disruptive factor for maintaining proper sodium handling. Although high-fat diets induce hypertension in both sexes, these data reveal that males are at greater risk of salt-dependent hypertension and further suggest that females have more redundant systems that can be productive against salt-sensitive hypertension in at least some circumstances.

Keyphrases

blood pressure
weight loss
insulin resistance
metabolic syndrome
electronic health record
type diabetes
weight gain
high fat diet induced
big data
genome wide
single cell
machine learning
physical activity
dna methylation