HDR brachytherapy decreases proliferation rate and cellular progression of a radioresistant human squamous cell carcinoma in vitro.

Jony M GeraldoSérgio ScalzoDaniela S ReisThiago L LeãoSilvia GuatimosimLuiz O LadeiraLidia M Andrade

Published in: International journal of radiation biology (2017)

HDR brachytherapy led to a decreased proliferation rate and cell survival and also hampered cellular progression to mitosis suggesting that tumor cell death mainly occurred due to mitotic death and G2/M cell cycle arrest.

Keyphrases

cell cycle arrest
cell death
high dose
squamous cell carcinoma
signaling pathway
pi k akt
locally advanced
radiation therapy
endothelial cells
low dose
cell cycle
induced pluripotent stem cells
rectal cancer
lymph node metastasis
cell proliferation
light emitting