Unraveling Dexamethasone-Induced Neurobehavioral and Sleep Problems in Children With ALL: Which Determinants Are Important?
Annelienke M van HulstMartha A GrootenhuisEmma Jacobine VerwaaijenRaphaele R L van LitsenburgLetao LiBertrand D van ZelstLinda BroerSaskia M F PluijmRob PietersMarta FioccoErica L T van den AkkerMarry M van den Heuvel-EibrinkPublished in: JCO precision oncology (2023)
We identified parenting stress, and not dexamethasone pharmacokinetics, genetic variation, patient/parent demographics, or disease/treatment characteristics, as a significant determinant for parent-reported dexamethasone-induced neurobehavioral and sleep problems. Parenting stress may be a modifiable target to reduce these problems.