Onset of Preclinical Alzheimer Disease in Monozygotic Twins.

Elles KonijnenbergJori TomassenAnouk den BraberMara Ten KateMaqsood YaqubSandra D MulderMichel G NivardHugo VandersticheleAdriaan A LammertsmaCharlotte E TeunissenBart N M van BerckelDorret I BoomsmaPhilip ScheltensBetty M TijmsPieter Jelle Visser

Published in: Annals of neurology (2021)

Our results suggest a substantial genetic/shared environmental background contributes to both Aβ and tau increases, suggesting that modulation of environmental risk factors may aid in delaying the onset of AD pathophysiological processes. ANN NEUROL 2021;89:987-1000.

Keyphrases

risk factors
human health
life cycle
mild cognitive impairment
genome wide
copy number
neural network
climate change
mesenchymal stem cells