Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas.
Giulia PericoliAngela GalardiAlessandro PaoliniLucia Lisa PetrilliGerardo PepeAlessandro PalmaMarta CollettiRoberta FerrettiEzio GiordaStefano Levi MorteraAnna BurfordAndrea CaraiAngela MastronuzziAlan MackayLorenza PutignaniChris JonesLuisa PascucciHector PeinadoManuela Helmer-CitterichEmmanuel de BillyAndrea MasottiFranco LocatelliAngela Di GiannataleMaria VinciPublished in: Cell & bioscience (2023)
In conclusion, our study highlights for the first time a key role for exosomes in the inter-clonal communication in PDHGG and suggests that interfering with the exosome biogenesis pathway may be a valuable strategy to inhibit cell motility and dissemination for these specific diseases.