Quantitative Diffusion and Spectroscopic Neuroimaging Combined with a Novel Early-Developmental Assessment Improves Models for 1-Year Developmental Outcomes.

Hunter G Moss L G WolfP Coker-BoltV RamakrishnanTurki K Aljuhani Milad Yazdani T R Brown Jens H Jensen Dorothea D Jenkins

Published in: AJNR. American journal of neuroradiology (2021)

Microstructural integrity of the major WM tracts and metabolism in the basal ganglia and frontal WM strongly correlate with early developmental performance, suggesting that the Specific Test of Early Infant Motor Performance reflects CNS integrity after preterm birth. This study demonstrates that combining quantitative neuroimaging and early functional movement improves the prediction of 12-month outcomes in premature infants.

Keyphrases

preterm birth
high resolution
low birth weight
blood brain barrier
working memory
white matter
preterm infants
molecular docking
molecular dynamics simulations