4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.

Wen-Tsan WengPing-Chang KuoDennis A BrownBarbara A ScofieldDestin FurnasHallel C ParaisoPei-Yu WangI-Chen YuJui-Hung Yen

Published in: Journal of neuroinflammation (2021)

Our work demonstrates that 4-EG confers protection against autoimmune disease EAE through modulating neuroinflammation and inhibiting Th1 and Th17 differentiation, suggesting 4-EG, a natural compound, could be potentially developed as a therapeutic agent for the treatment of MS/EAE.

Keyphrases

multiple sclerosis
lipopolysaccharide induced
traumatic brain injury
signaling pathway
lps induced
cognitive impairment
mass spectrometry
cerebral ischemia
ms ms
inflammatory response