Definition of Virological Endpoints Improving the Design of Human Immunodeficiency Virus (HIV) Cure Strategies Using Analytical Antiretroviral Treatment Interruption.
Marie AlexandreMélanie PragueEdouard LhommeJean-Daniel LelièvreLinda WittkopLaura RichertYves LévyRodolphe ThiebautPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Our results are in line with recommendations and emphasize the benefits of an ATI phase >12 weeks, with regular monitoring, and a virological ART restart criterion of 10 000 copies/mL to limit the risk for patients while capturing enough information to keep nAUC as an optimal proxy to the setpoint.
Keyphrases
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- hiv positive
- hiv infected patients
- hiv aids
- hepatitis c virus
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- hiv testing
- patient reported
- liquid chromatography
- patient reported outcomes
- south africa
- preterm birth
- clinical practice