One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles.
Grigorii K SterligovAlexandra A AgeshinaSergey A RzhevskiyOlga V ShurupovaMaxim A TopchiyLidiya I MinaevaAndrey F AsachenkoPublished in: ACS omega (2022)
A One-pot, two-step procedure for the synthesis of 1,2-disubstituted-3-tosyl and 1,2-disubstituted-3-cyanoindoles from the corresponding N -( o -tolyl)benzamides is reported. The developed procedure is operationally simple, does not utilize any transition metals, and provides variably substituted indoles in good yields from readily available starting materials.