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RETaliation - tackling rare resistance alterations to osimertinib.

Matthew G KrebsSanjay Popat
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
RET fusions occur as a rare mechanism of acquired resistance to osimertinib in epidermal growth factor receptor mutation (EGFRm) positive non-small cell lung cancer (NSCLC) patients. Inhibiting RET alongside osimertinib shows promising clinical activity but innovative approaches are needed to seek regulatory approvals in these rare treatment resistance settings.
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