Investigating low birth weight and preterm birth as potential mediators in the relationship between prenatal infections and early child development: a linked administrative health data analysis.
Iain HardieAja MurrayJosiah KingHildigunnar Anna HallKenneth OkeloEmily LuedeckeLouise MarryatLucy ThompsonHelen MinnisMichael LombardoPhilip WilsonBonnie AuyeungPublished in: Journal of epidemiology and community health (2024)
Low birth weight and preterm birth appear to mediate the relationship between prenatal infections and childhood development, but only to a small extent. Maternal immune activation mechanisms unrelated to low birth weight and preterm birth remain the most likely explanation for associations observed between prenatal infections and child developmental outcomes, although other factors (for example, genetic factors) may also be involved.
Keyphrases
- preterm birth
- low birth weight
- human milk
- data analysis
- pregnant women
- gestational age
- mental health
- birth weight
- healthcare
- public health
- preterm infants
- type diabetes
- body mass index
- copy number
- human health
- health information
- young adults
- dna methylation
- risk assessment
- pregnancy outcomes
- insulin resistance
- gene expression
- cord blood
- skeletal muscle
- metabolic syndrome
- weight loss