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White matter repair and treatment strategy after intracerebral hemorrhage.

Yi-Bin JiangKai-Yan WeiXu-Yang ZhangHua FengRong Hu
Published in: CNS neuroscience & therapeutics (2019)
The predilection site of intracerebral hemorrhage (ICH) is in the basal ganglia, which is rich in white matter (WM) fiber bundles, such as cerebrospinal tract in the internal capsule. ICH induced damage to this area can easily lead to severe neurological dysfunction and affects the prognosis and quality of life of patients. At present, the pathophysiological mechanisms of white matter injury (WMI) after ICH have attracted researchers' attention, but studies on the repair and recovery mechanisms and therapy strategies remain rare. In this review, we mainly summarized the WM recovery and treatment strategies after ICH by updating the WMI-related content by reviewing the latest researches and proposing the bottleneck of the current research.
Keyphrases
  • white matter
  • multiple sclerosis
  • working memory
  • brain injury
  • oxidative stress
  • drug induced
  • diabetic rats
  • high glucose
  • stem cells
  • replacement therapy
  • combination therapy
  • cell therapy