Comparative diagnostic utility of metagenomic next-generation sequencing, GeneXpert, modified Ziehl-Neelsen staining, and culture using cerebrospinal fluid for tuberculous meningitis: A multi-center, retrospective study in China.
Yuxin ChenYuqing WangXiaojin LiuWen LiHongyi FuXinyan LiuXun ZhangXueqin ZhouBingzhou YangJie YaoXiaolei MaLijun HanHuan LiLiheng ZhengPublished in: Journal of clinical laboratory analysis (2022)
Metagenomic next-generation sequencing detected TBM with higher sensitivity than Xpert, ZN staining and MGIT culture, but mNGS cannot be used as a rule-out test. mNGS combined with Xpert or modified ZN staining could enhance the sensitivity of diagnostic tests for TBM.