TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs.

Elena CambriaSally HeusserAriane C ScheurenWai Kit TamAgnieszka A KarolWolfgang HitzlVictor Y LeungRalph MüllerStephen J FergusonKarin Wuertz-Kozak

Published in: JOR spine (2021)

TRPV4 therefore regulates COX2/PGE2 and mediates cell damage induced by hyperphysiological dynamic compression, possibly via ERK. Targeted TRPV4 inhibition or knockdown might thus constitute promising therapeutic approaches to treat patients suffering from IVD pathologies caused by aberrant mechanical stress.

Keyphrases

single cell
end stage renal disease
oxidative stress
ejection fraction
cell therapy
neuropathic pain
newly diagnosed
signaling pathway
prognostic factors
cancer therapy
mesenchymal stem cells
patient reported outcomes
pi k akt
heat stress