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Characterizing interactions of Leptospira interrogans with proximal renal tubule epithelial cells.

Takayoshi YamaguchiNaomi HigaNobuhiko OkuraArina MatsumotoIdam HermawanTetsu YamashiroToshihiko SuzukiClaudia Toma
Published in: BMC microbiology (2018)
After hematogenous dissemination, leptospires create protective and replicative niches in the base membrane and luminal sides of the RPTECs. During the long-term colonization, leptospires attached to the RPTEC brush borders and membrane vesicles might be involved in the formation of a biofilm-like structure in vivo. Our results also suggested that the virulent strain is able to manipulate host cell stress responses to promote renal colonization.
Keyphrases
  • pseudomonas aeruginosa
  • staphylococcus aureus
  • single cell
  • candida albicans
  • biofilm formation
  • escherichia coli
  • mesenchymal stem cells