Impact of cholesterol on proinflammatory monocyte production by the bone marrow.
Lotte C A StiekemaLisa WillemsenYannick KaiserKoen H M PrangeNicholas J WarehamS Matthijs BoekholdtCarlijn KuijkMenno P J de WintherCarlijn VoermansMatthias NahrendorfErik S G StroesJeffrey KroonPublished in: European heart journal (2021)
Collectively, these data highlight that LDL-C impacts haematopoiesis, promoting both the number and the proinflammatory activation of circulating monocytes. Furthermore, this study reveals a potential contributory role of HSPC transcriptomic reprogramming to residual inflammatory risk in FH patients despite cholesterol-lowering therapy.
Keyphrases
- bone marrow
- end stage renal disease
- low density lipoprotein
- newly diagnosed
- ejection fraction
- chronic kidney disease
- mesenchymal stem cells
- prognostic factors
- peritoneal dialysis
- electronic health record
- oxidative stress
- single cell
- peripheral blood
- stem cells
- machine learning
- patient reported outcomes
- deep learning
- climate change