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Genetic factors for differentiated thyroid cancer in French Polynesia: new candidate loci.

Monia ZidaneMarc HaberThérèse TruongFrédérique RachédiCatherine OrySylvie ChevillardHélène BlanchéRobert OlasoAnne BolandÉric ConteMojgan KarimiYan RenConstance XhaardVincent SouchardJacques GardonMarc TaquetAndré BouvilleJean-François DeleuzeVladimir DrozdovitchFlorent de VathaireJean-Baptiste Cazier
Published in: Precision clinical medicine (2023)
Our study results suggest a role of the loci 6q24.3, 10p12.2 and 17q21.32 in DTC risk. However, a whole genome sequencing approach would be better suited to characterize these factors than genotyping with microarray chip designed for the Caucasian population. Moreover, the functional impact of these three new loci needs to be further explored and validated.
Keyphrases
  • genome wide
  • dna methylation
  • genome wide association study
  • genome wide association
  • copy number
  • high throughput
  • papillary thyroid
  • gene expression
  • squamous cell
  • squamous cell carcinoma
  • childhood cancer