The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease.
Maria Carolina DalmassoItziar de RojasNatividad OlivarCarolina MuchnikBárbara AngelSergio GlogerMariana Soledad Sanchez AbalosMaría Victoria ChacónRafael AránguizPaulina OrellanaCarolina CuestaPablo GaleanoLorenzo CampanelliGisela Vanina NovackLuis Eduardo MartinezNancy MedelJulieta LissoZulma SevillanoNicolás IruretaEduardo Miguel CastañoLaura MontrrealMichaela ThoenesClaudia HansesStefanie Heilmann-HeimbachClaudia KairiyamaInés MintzIvana VillellaFabiana RuedaAmanda RomeroNancy WukitsevitsIvana QuirogaCristian GonaJean-Charles LambertPatricia SolisDaniel Gustavo PolitisCarlos Alberto MangoneChristian Gonzalez-BillaultMercè BoadaLluís TàrragaAndrea SlachevskyCecilia AlbalaPatricio FuentesSilvia KochenLuis Ignacio BruscoAgustín RuizLaura MorelliAlfredo RamirezPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
This is the first genome-wide association study on Alzheimer's disease (AD) in a population sample from Argentina and Chile. Trans-ethnic meta-analysis reveals four new loci involving lysosomal function in AD. This is the first independent replication for TREM2L, IGH-gene-cluster, and ADAM17 loci. A genetic risk score (GRS) developed in Europeans performed well in this population. The higher the Native American ancestry the lower the GRS values.