HLA-A*24:07 as a potential biomarker for carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Filipino patients.
Francis R CapulePramote TragulpiankitSurakameth MahasirimongkolJiraphun JittikoonNuanjun WichukchindaLara Theresa Alentajan-AletaJay-V James G BaritJosephine Casanova-GutierrezLeonor Cabral-LimJose Paciano Baltazar ReyesFrancisca RoaRaymark SalongaKatrina Faith San GabrielCatherine Lynn SilaoPublished in: Pharmacogenomics (2021)
Aim: A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Materials & methods: A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted from saliva samples was genotyped. Statistical analysis was done. Results: The HLA-B75 serotype (p = 0.003; odds ratio [OR] = 13.8; 95% CI = 2.5-76.8), HLA-B*15:21 (p = 0.041; OR = 4.7; 95% CI = 1.1-20.8) and HLA-A*24:07 (p = 0.032; OR = 6; 95% CI = 1.2-30.7) were significantly associated with carbamazepine-induced SJS/TEN. Conclusion: The HLA-B75 serotype, HLA-B*15:21 or HLA-A*24:07 may be used for pharmacogenetic screening prior to prescribing carbamazepine in Filipinos.
Keyphrases
- high glucose
- end stage renal disease
- diabetic rats
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- primary care
- emergency department
- endothelial cells
- peritoneal dialysis
- oxidative stress
- dengue virus
- dna methylation
- electronic health record
- machine learning
- gene expression
- klebsiella pneumoniae
- patient reported
- deep learning
- data analysis