Unique characteristics of tertiary lymphoid structures in kidney clear cell carcinoma: prognostic outcome and comparison with bladder cancer.

Tsukasa MasudaNobuyuki TanakaKimiharu TakamatsuKyohei HakozakiRyohei TakahashiTadatsugu AnnoRyohei KufukiharaKazunori ShojoShuji MikamiToshiaki ShinojimaKazuhiko KakimiTatsuhiko TsunodaEriko AimonoHiroshi NishiharaRyuichi MizunoMototsugu Oya

Published in: Journal for immunotherapy of cancer (2022)

The immunobiology of ccRCC is unique, and various cancerous phenomena conflict with that seen in other cancer types; therefore, comparing the TLS characteristics between ccRCC and bladder cancer may help reveal differences in the prognostic impact, maturity and spatial distribution of TLSs and in the immune environment surrounding TLSs between the two cancers.

Keyphrases

clear cell
papillary thyroid
squamous cell
single cell
squamous cell carcinoma
gene expression
dna methylation
young adults
clinical evaluation