A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinoma.

Tatiana Correa Douglas E Laux Henry T Hoffman

Published in: Clinical case reports (2020)

Pathogenic germline BRCA2 variants may be associated with an increased risk of hypopharyngeal squamous cell carcinoma that is more responsive to chemoradiation and chemotherapeutics targeting defective double-strand DNA repair.

Keyphrases

dna repair
squamous cell carcinoma
locally advanced
dna damage
cancer therapy
dna damage response
rectal cancer
lymph node metastasis
case report
breast cancer risk
copy number
gene expression
oxidative stress
radiation therapy