Cognitive and Functional Change Over Time in Cognitively Healthy Individuals According to Alzheimer Disease Biomarker-Defined Subgroups.
Mark A DubbelmanHeleen M A HendriksenJohn E HarrisonEverard G B VijverbergNiels D PrinsLior A KroezeLois OttenhoffMardou M S S A Van LeeuwenstijnInge M W VerberkCharlotte E TeunissenElsmarieke Van De GiessenArgonde C Van HartenWiesje Maria van der FlierSietske A M SikkesPublished in: Neurology (2023)
In conclusion, functional, composite, and neuropsychological outcome measures across all cognitive domains detect changes over time in various biomarker-defined groups, with changes being most evident among individuals with more AD pathology. AD prevention trials should use sufficiently long follow-up duration and/or more sensitive outcome measures to optimally capture subtle cognitive changes over time.