The current study provides compelling evidence that RK effectively inhibits the TLR-4/NF-κB pathway via the gut-brain axis, leading to the improvement of LPS-induced depression-like behaviors in mice. This study addresses the research gap in understanding the antidepressant effects of RK and illuminates the potential of utilizing RK as a functional food for preventing depression.
Keyphrases
- lps induced
- inflammatory response
- signaling pathway
- toll like receptor
- depressive symptoms
- pi k akt
- immune response
- white matter
- oxidative stress
- high fat diet induced
- type diabetes
- major depressive disorder
- mouse model
- resting state
- human health
- adipose tissue
- cell proliferation
- bipolar disorder
- climate change
- skeletal muscle
- insulin resistance