Prospective evaluation of a breast-cancer risk model integrating classical risk factors and polygenic risk in 15 cohorts from six countries.
Amber N HursonParichoy Pal ChoudhuryChi GaoAnika HüsingMikael ErikssonMin ShiMichael E JonesD Gareth R EvansRoger L MilneMia M GaudetCeline M VachonDaniel I ChasmanDouglas F EastonMarjanka K SchmidtPeter KraftMontserrat Garcia-ClosasNilanjan Chatterjeenull nullPublished in: International journal of epidemiology (2021)
Integrating a 313-variant PRS with classical risk factors can improve the identification of European-ancestry women at elevated risk who could benefit from targeted risk-reducing strategies under current clinical guidelines.