Association of age, sex and BMI with the rate of change in tibial cartilage volume: a 10.7-year longitudinal cohort study.

Tibial cartilage volume declines at a faster rate with increasing age and body mass index in both males and females, particularly in the medial compartment. In contrast to the low rate of change in radiographs, our findings suggest that cartilage loss at the tibia is universal in this age group.