Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer's disease.
Giuseppa MudòMonica FrinchiDomenico NuzzoPietro ScadutoFulvio PlesciaMaria F MassentiMarta Di CarloCarla CannizzaroGiovanni CassataLuca CiceroMaria RuscicaNatale BelluardoLuigi M GrimaldiPublished in: Journal of neuroinflammation (2019)
This study shows that IFNβ1a is able to reverse the inflammatory and cognitive effects of intra-hippocampal Aβ1-42 in the rat. Given the role played by inflammation in AD pathogenesis and the established efficacy of IFNβ1a in the treatment of inflammatory diseases of the central nervous system such as multiple sclerosis, its use may be a viable strategy to inhibit the pro-inflammatory cytokine and oxidative stress cascade associated with Aβ deposition in the hippocampus of AD patients.
Keyphrases
- oxidative stress
- dendritic cells
- multiple sclerosis
- end stage renal disease
- immune response
- anti inflammatory
- ejection fraction
- chronic kidney disease
- induced apoptosis
- ischemia reperfusion injury
- diabetic rats
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- cerebral ischemia
- cognitive decline
- white matter
- cerebrospinal fluid
- subarachnoid hemorrhage
- patient reported
- endoplasmic reticulum stress
- prefrontal cortex