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Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer's disease.

Giuseppa MudòMonica FrinchiDomenico NuzzoPietro ScadutoFulvio PlesciaMaria F MassentiMarta Di CarloCarla CannizzaroGiovanni CassataLuca CiceroMaria RuscicaNatale BelluardoLuigi M Grimaldi
Published in: Journal of neuroinflammation (2019)
This study shows that IFNβ1a is able to reverse the inflammatory and cognitive effects of intra-hippocampal Aβ1-42 in the rat. Given the role played by inflammation in AD pathogenesis and the established efficacy of IFNβ1a in the treatment of inflammatory diseases of the central nervous system such as multiple sclerosis, its use may be a viable strategy to inhibit the pro-inflammatory cytokine and oxidative stress cascade associated with Aβ deposition in the hippocampus of AD patients.
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