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Strategic Construction of meso -Aryl-Substituted N,N -Carbonyl-Bridged Dipyrrinones as Small, Bright, and Tunable Fluorophores.

Yingjian ShangZhongxin LiZhaoyang ZhuLuying GuoQinghua WuXing GuoLei ZhangChangjiang YuErhong HaoLijuan Jiao
Published in: Organic letters (2024)
A series of novel N , N -carbonyl-bridged dipyrrinone fluorophores have been directly constructed from α-halogenated dipyrrinones, which are conveniently obtained from the acid-catalyzed hydrolysis of readily available α,α'-dihalodipyrrins. This novel methodology affords efficient modulation of the functional groups at both the meso - and α-positions of this fluorophore. These resultant dyes show tunable absorption and emission wavelengths, good molar absorption coefficients, relatively large Stokes shifts, and excellent fluorescence quantum yields up to 0.99, and have been successfully applied in both one- and two-photon fluorescence microscopy imaging in living cells.
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