Time-encoded ASL reveals lower cerebral blood flow in the early AD continuum.
Carles FalconPaula MontesinosLena VáclavůMichalis KassinopoulosCarolina MinguillonKarine FauriaDiego Cascales-LahozJosé ContadorAida Fernández-LebreroIrene NavalpotroAlbert Puig-PijoanOriol Grau-RiveraGwendlyn KollmorgenClara Quijano-RubioJosé Luis MolinuevoHenrik ZetterbergKaj BlennowMarc Suárez-CalvetMatthias J P Van OschJavier Sanchez-GonzalezJuan-Domingo GispertPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Lower CBF can be detected in CU subjects in the early AD continuum. te-ASL is more sensitive than single-PLD ASL at detecting CBF alterations in AD. CBF is linked to biomarkers of AD, synaptic dysfunction, and neurodegeneration.
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