Switch of innate to adaptative immune responses in the brain of patients with Alzheimer's disease correlates with tauopathy progression.
Marcos Romualdo CostaPublished in: npj aging (2024)
Neuroinflammation is a key feature of Alzheimer's disease (AD). In this work, analysis of single- cell RNA-sequencing (scRNA-seq) data obtained from the brain of patients with AD provides evidence supporting a switch from an innate to an adaptative immune response during tauopathy progression, with both disease-associated microglia (DAM) and CD8+ T cells becoming more frequent at advanced Braak stages.
Keyphrases
- immune response
- single cell
- rna seq
- dendritic cells
- toll like receptor
- white matter
- resting state
- cognitive decline
- traumatic brain injury
- high throughput
- machine learning
- cerebral ischemia
- multiple sclerosis
- genome wide
- functional connectivity
- big data
- deep learning
- dna methylation
- brain injury
- subarachnoid hemorrhage
- lps induced