Design and construction of competitive, noncompetitive and uncompetitive nano inhibitors of enzymes.
Wen-Qi ChenYing-Qi YuLing CaoMiao-Miao YinYi LiuFeng-Lei JiangPublished in: Chemical communications (Cambridge, England) (2022)
Three common types of reversible inhibitors, namely competitive, noncompetitive and uncompetitive inhibitors, were designed and constructed by using enzymes with different surface charges and gold nanoparticles with different surface ligands and particle sizes. To our knowledge, it is the first time that an uncompetitive nano inhibitor has been discovered.