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Intrauterine hyperglycemia induces SIRT3-mediated mitochondrial dysfunction: the fetal origin pathogenesis of precocious osteoarthritis.

Xinyuan LiWanbo ZhuYi ChengZhuoran RenXinmei LiuHongbo YangGuolian DingHefeng Huang
Published in: Osteoarthritis and cartilage (2024)
Our study revealed a significantly increased susceptibility to OA in the gestational diabetes mellitus offspring, which is partly attributed to exposure to adverse factors in utero and ultimately to the onset of disease via epigenetic modulation.
Keyphrases
  • knee osteoarthritis
  • dna methylation
  • pregnant women
  • gene expression
  • rheumatoid arthritis
  • high fat diet
  • type diabetes
  • ischemia reperfusion injury
  • metabolic syndrome
  • adverse drug
  • electronic health record